Genetics of non-insulin-dependent diabetes mellitus (NIDDM)
نویسندگان
چکیده
منابع مشابه
The genetics of non-insulin-dependent diabetes mellitus.
NIDDM is one of the commonest metabolic disorders encountered in clinical practice, affecting an estimated 3% of the population of the Western World [1]. Prevalence data from Africa have recently been reviewed [2] and it appears that NIDDM has a prevalence in South Africa comparable to that found in developed countries, with a similar rate in rural and urban populations. In the northern part of...
متن کاملGenetics of insulin-dependent diabetes mellitus.
Recent studies that have focused on the detection of non-MHC susceptibility loci in insulin-dependent diabetes mellitus are reviewed. It has been confirmed that the region on human chromosome 11p contains such a susceptibility locus and recent research has attempted to identify the causative DNA variants and their functional role in disease.
متن کاملNon-insulin-dependent diabetes mellitus.
Non-insulin-dependent diabetes mellitus (NIDDM) occurs predominantly after the age of 50 years but is not easy to distinguish from late onset insulin-dependent diabetes. It is likely that misclassification is rare in a Caucasian population. Whilst NIDDM is widely believed to be genetically determined, recent epidemiological observations have consistently revealed statistical associations betwee...
متن کاملEtiology and Pathogenesis of Non-insulin dependent Diabetes Mellitus (NIDDM): Current concepts
We discuss the etiopathogenesis of NIDDM in the light of new data. The role of insulin deficiency and insulin resistance is discussed. The ultrastructure of amylin in the islet cells is described. The role of abnormalities in hepatic glucose metabolism is discussed. The effect of glucotoxicity on the islet cell funtion is brought out. We have attempted to construct the teleological sequence of ...
متن کاملBlood and liver lipid concentrations in EDS shrews exhibiting spontaneous non-insulin dependent diabetes mellitus (NIDDM).
The EDS (early-onset diabetes in suncus) colony was developed as a new laboratory colony of the musk shrew and is characterized by a high incidence of early-onset spontaneous non-insulin dependent diabetes mellitus (NIDDM). We examined blood lipid (triglyceride [TG], total cholesterol [TC], phospholipid [PL], free fatty acid [FFA]) and liver lipid (TG, TC, PL) concentrations to investigate the ...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 1993
ISSN: 0954-6820,1365-2796
DOI: 10.1111/j.1365-2796.1993.tb00774.x